Augmented MRI Endpoints in a Phase II Crohn’s Program
Adding functional motility metrics to a Phase II Crohn's imaging protocol to sharpen the read on treatment response.
Gastroenterology 01 — Situation
The scientific question behind the program.
This case study outlines an early-phase imaging challenge and the endpoint strategy Fidēs designed to answer the biological question at hand. Replace this with the program-specific narrative.
02 — Our Approach
Designing imaging endpoints around the biology.
Fidēs aligned the imaging strategy with the study’s decision points, implementing quantitative measures appropriate to the indication and modality.
03 — Impact
Clearer, earlier decisions.
The approach delivered a richer, more sensitive read-out to support the go / no-go decision. Replace with the measured outcome.
Other case studies
Gastroenterology The Role of Movement in Characterising Treatment Response in IBD
Augmenting standard MRI endpoints with motility measures to deliver a more complete characterisation of biological response in Crohn's disease.
Read case study
Gastroenterology The Power of Movement: Motion as an Imaging Endpoint
Augmenting standard MRI endpoints with motility measures to deliver a more complete characterisation of biological response in Crohn's disease.
Read case study
Gastroenterology Structural and Functional MRI Assessment in Post-Surgical J-Pouch Patients
Combining structural and functional MRI to characterise pouch function and inflammation in post-surgical J-pouch patients.
Read case study
Oncology Uterine Contractility as a Quantitative Endpoint in Early-Phase Gynaecology Trials
Establishing uterine contractility as a quantitative, reproducible imaging endpoint for early-phase gynaecology trials.
Read case study
Oncology Beyond RECIST: Additive Imaging Endpoints in Solid Tumour Trials
How augmented endpoint analysis provides earlier and more interpretable signals than standard volumetric measures alone.
Read case study
Oncology Live Data Visibility in Phase I Imaging Trials
A review of how real-time imaging access changes sponsor behaviour and supports earlier go / no-go decisions in early development.
Read case study
Gastroenterology Cine-MRI Motility Analysis as a Primary Endpoint
Using cine-MRI motility analysis as a primary endpoint to detect functional change earlier than structural measures alone.
Read case study